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But I did go back to a couple of the people Id spoken with and asked them about the rebellious and nihilistic angle, and they pushed back on that framing, at least in LA

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While the precise cellular and network mechanisms that underly nicotine induced seizures are not fully elucidated, the cholinergic nuclei in the brainstem and basal forebrain play key roles in arousal and attention via their effects on cortical tone and modulation of such systems could therefore theoretically affect the seizure threshold

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